fill in Angular form from vanilla JS changes not being detected

I have an angular single page with a form and some controls (template driven).
Now for some reason I need to fill in input fields from vanilla JS outside Angular (from for example the console or Puppeteer).

When I fill in the input fields by non-Angular javascript code the value is filled in, but nothing happens in the Angular world.

I tried triggering change detection through ApplicationRef or ChangeDetectionRef within ngZone.run() but the changes applied are not being detected.
How can I make this work?

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Source Url fill in Angular form from vanilla JS changes not being detected